Assessment of Some Biochemical Parameters to Evaluate the Endothelial Function in Patients with Sickle Cell Disease

الملخص

Sickle cell disease (SCD) is hematological disease that affects the endothelial function. The hemoglobinopathy of this disease triggers erythrocyte polymerization. The sickling process leads to vascular occlusion, tissue hypoxia and subsequent reperfusion injury, thus inducing inflammation and endothelial injury (EI). Thirty sickle disease patients (15 females and 15 males) with a mean age of (27.0 ± 8.9) and 30 healthy controls (18 females and 12 males) with a mean age of (129.7 ± 9.1) participated in the study. Assessments of endothelial function done by studying biochemical parameters which includes; serum nitric oxide, serum endothelin-1, vascular cell adhesion molecule-1, and serum interlukin-6. The results showed that all the biochemical parameters that measured in this study were not significantly different between the patients with sickle cell disease and control subjects, except the serum level of nitric oxide in the sickle cell disease patients (2.90 ± 2.57) was significantly lower (P = 0.02) than that of controls (8.49 ± 9.36). From all these findings, we can conclude that SCD patients have some degree of impairment of endothelial function.