Study The Role of Selenium in The P-Selectin and E-Cadherin Serum Levels in Women with Preeclampsia.

الملخص

Preeclampsia (PE) is characterized by endothelial dysfunction with vasoconstriction due to cell adhesion molecules or mediators released by defective placentation. Platelet selectin (P-selectin) and epithelial cadherin (E-cadherin) are the cell adhesion molecules, is elevated in many inflammatory conditions including PE. Objective To investigate if P-selectin and E-cadherin levels can be used as a marker for adverse outcomes in pregnancy complicated with PE. Patients and Method This study involved 90 pregnant women in their third trimester of pregnancy divided into2 group: Group A: involves 45 pregnant women with PE. Group B involve 45 healthy pregnant women and normal fetal growth (Control group). Result The results show there were a high significant increase in the mean values of P-selectin with high increase in the mean values of E-cadherin in PE group when compared to control group. ROC curve …