Maternal plasma kisspeptin‐10 level in preeclamptic pregnant women and its relation in changing their reproductive hormones

الملخص

Abstract Aims To evaluate plasma kisspeptin‐10 (KP‐10) as a marker for preeclampsia and assess its relation to altered reproductive hormones in preeclamptic pregnant women. Methods First time pregnant women (n = 100) at 20 weeks of gestation participated in this study and divided into preeclamptics (n = 60) and normotensives (n = 40). KP‐10, luteinizing hormone (LH), follicle-stimulating hormone (FSH), beta‐human chorionic gonadotropin (β‐hCG), estradiol (E2) and progesterone were evaluated during 2nd and 3rd trimesters of pregnancy for all women. Results Kisspeptin‐10 levels were reduced in preeclampsia (PE) women compared with normotensive pregnancies. In the 2nd trimester, area under receiver–operator characteristic (ROC) curve was 0.662, positive and negative predictive values were 32.8 and 94.6, and test sensitivity and specificity were 55% and 87.5%, respectively. In the 3rd trimester, area under ROC curve was 0.747 positive and negative predictive values were 22.2 and 97.3, and test sensitivity and specificity were 83.3% and 67.5%, respectively. In PE patients, plasma KP‐10 demonstrated an inverse correlation with E2 (during the 2nd trimester), LH and FSH (during the 3rd trimester), and positively correlated with β‐hCG (during the 3rd trimester). Conclusion This study showed significantly reduced plasma KP‐10 levels in PE women. This suggests that KP‐10 may play an important role in the pathophysiology of PE. Therefore, combined with previous studies, to diagnose the PE, testing for maternal KP‐10 plasma levels may be useful as an effective screening, but because of low positive predictive value and inadequate test sensitivity, screening cannot be recommended. Furthermore, KP‐10 in PE patients demonstrated a significant positive correlation with β‐hCG.