Interleukin-1β, 27 Level in Stimulated and Non-stimulated PCOS Infertile Women (Cross-Sectional Study)

الملخص

Abstract BACKGROUND: Polycystic ovary syndrome (PCOS) stands for highly prevalent female endocrine pathology. Females suffering from PCOS have a significantly higher number of inflammatory markers. The IL-1 family members enormously affect the innate immune system. AIM: Study the changes in the levels of Interleukin-1ß and Interleukin-27 in the stimulated and non-stimulated cycle (by gonadotrophin) in polycystic ovarian syndrome women. METHODS: Fifty-eight infertile women with polycystic ovary syndrome (PCOS) have been included in this research article. Twenty-nine of them did not undergo ovulation induction (OI) protocols, while the other 29 were under ovulation induction (OI) therapy. Interleukin-1ß and Interleukin-27 measured in both groups, in the stimulated cycle just before administration of HCG and on the 2nd day of the menstrual cycle in the non-stimulated females. RESULTS: Both interleukins have been significantly more significant in the ovulation stimulated group than the nonstimulated one, with p-value of (0.04) for interleukin -1ß and (0.02) for interleukin-27. CONCLUSION: The ovulation processes involve an increase in the inflammatory process, as demonstrated by the rise in these interleukins’ levels. This increase is more prominent in the process of ovulation induction.